HMGCR Polyklonaler Antikörper

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HMGCR Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13533-1-PBS

Synonyme

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  IHC staining of human liver cancer using 13533-1-AP (same clone as 13533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 13533-1-AP (HMGCR antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human liver cancer using 13533-1-AP (same clone as 13533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 13533-1-AP (HMGCR antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

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  IHC staining of human heart using 13533-1-AP (same clone as 13533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 13533-1-AP (HMGCR Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human heart using 13533-1-AP (same clone as 13533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 13533-1-AP (HMGCR Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

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  IHC staining of human small intestine using 13533-1-AP (same clone as 13533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 13533-1-AP (HMGCR antibody) at dilution of 1:1000 (under 10x lens).. This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human small intestine using 13533-1-AP (same clone as 13533-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 13533-1-AP (HMGCR antibody) at dilution of 1:1000 (under 40x lens).. This data was developed using the same antibody clone with 13533-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

13533-1-PBS bindet in IHC, Indirect ELISA HMGCR und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: HMGCR fusion protein Ag4444
• Vollständiger Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
• Berechnetes Molekulargewicht: 888 aa, 95 kDa
• GenBank-Zugangsnummer: BC033692
• Gene symbol: HMGCR
• Gene ID (NCBI): 3156
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

HMGCR(3-hydroxy-3-methylglutaryl-coenzyme A reductase) is also named as HMG-CoA reductase and belongs to the HMG-CoA reductase family. This protein exists as a 97-kDa glycoprotein in the endoplasmic reticulum (ER) and is the rate-determining enzyme of the biosynthesis pathway(PMID:15830340).The ectopic expression of either full-length HMGCR or its novel splice variant promotes dysregulation of the MVA pathway. And the ectopic expression of cHMGCR-FL(60 kDa) and cHMGCR-D13(55 kDa) can be detected in HepG2 cells(PMID:20696928).This protein is also can exsit as a oligomer(PMID:20696928).