HNF4A Rekombinanter Antikörper

HNF4A Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241593C4

Kat-Nr. : 84316-3-PBS

Synonyme

241593C4, Hepatocyte nuclear factor 4-alpha, HNF 4 alpha, HNF4, HNF4a7

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  WB analysis of HepG2 using 84316-3-RR (same clone as 84316-3-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 84316-3-RR (HNF4A antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84316-3-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

84316-3-PBS bindet in WB, Indirect ELISA HNF4A und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: HNF4A fusion protein Ag24647
• Vollständiger Name: hepatocyte nuclear factor 4, alpha
• Berechnetes Molekulargewicht: 53 kDa
• Beobachtetes Molekulargewicht: 56 kDa
• GenBank-Zugangsnummer: BC137539
• Gene symbol: HNF4A
• Gene ID (NCBI): 3172
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

HNF4A (Hepatocyte nuclear factor 4 α) is highly conserved between humans and mice. Using conditional knockouts, epithelial HNF4A is indispensable for protecting against acute chemical-induced colitis and spontaneous colonic inflammation in aged animals (PMID:35792863). Moreover, reduced expression of HNF4A has been reported in liver fibrosis and viral vector-mediated HNF4A restoration has previously been demonstrated to reverse features of chronic liver injury. Therefore, HNF4A has been suggested as a therapeutic target for treating liver fibrosis (PMID:34453962).