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HPSE2 Polyklonaler Antikörper

HPSE2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21128-1-PBS

Synonyme

heparanase 2, Hpa2, HPR2, Inactive heparanase-2

Filter:
  • Western Blot (WB) analysis of L02 cells using HPSE2 Polyclonal antibody (21128-1-AP)

    WB analysis of L02 using 21128-1-AP (same clone as 21128-1-PBS)

    L02 cells were subjected to SDS PAGE followed by western blot with 21128-1-AP (HPSE2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21128-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of L02 cells using HPSE2 Polyclonal antibody (21128-1-AP)

    WB analysis of L02 using 21128-1-AP (same clone as 21128-1-PBS)

    L02 cells were subjected to SDS PAGE followed by western blot with 21128-1-AP (HPSE2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21128-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

21128-1-PBS bindet in WB, Indirect ELISA HPSE2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen HPSE2 fusion protein Ag15526
Vollständiger Name heparanase 2
Berechnetes Molekulargewicht 592 aa, 67 kDa
Beobachtetes Molekulargewicht 54 kDa, 66 kDa
GenBank-ZugangsnummerBC112356
Gene symbol HPSE2
Gene ID (NCBI) 60495
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

HPSE2 (heparanase 2) is a homolog of HPSE (heparanase 1). HPSE is an endo-β-glucuronidase that cleaves heparan sulfate proteoglycans (HSPGs), which are important components of the extracellular matrix and basement membranes. HPSE2, however, lacks intrinsic heparan sulfate-degrading activity. Instead, it binds to heparan sulfate with higher affinity than HPSE, thereby competing with HPSE for heparan sulfate binding and inhibiting HPSE's enzymatic activity. This competitive inhibition makes HPSE2 a crucial regulator of heparan sulfate metabolism.