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HYAL1 Monoklonaler Antikörper

HYAL1 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1B8B5

Kat-Nr. : 66560-1-PBS

Synonyme

1B8B5, EC:3.2.1.35, HYAL 1, Hyal-1, Hyaluronidase 1

Filter:
  • Western Blot (WB) analysis of HepG2 cells using HYAL1 Monoclonal antibody (66560-1-Ig)

    WB analysis of HepG2 using 66560-1-Ig (same clone as 66560-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 66560-1-Ig (HYAL1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66560-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

66560-1-PBS bindet in WB, Indirect ELISA HYAL1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen HYAL1 fusion protein Ag18183
Vollständiger Name hyaluronoglucosaminidase 1
Berechnetes Molekulargewicht 435 aa, 48 kDa
Beobachtetes Molekulargewicht 60 kDa
GenBank-ZugangsnummerBC035695
Gene symbol HYAL1
Gene ID (NCBI) 3373
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Hyaluronic acid (HA) is a glycosaminoglycan that is believed to have numerous important biologic functions, including modulation of cell proliferation, migration, and differentiation, as well as the regulation of extracellular water and protein homeostasis. It is also an integral structural component of cartilage and other tissues and acts as a lubricant in joints. Hyaluronidases are a family of enzymes that catalyse the degradation of HA. In humans, there are five functional hyaluronidases: HYAL1, HYAL2, HYAL3, HYAL4 and HYAL5 (also known as SPAM1 or PH-20); plus a pseudogene, HYAL6 (also known as HYALP1). HYAL-1 is present in many tissues and is predominantly found in the plasma and urine (PMID: 16600643). In addition to its function in normal cellular hyaluronan turnover, human HYAL-1 is implicated in cancer proliferation, angiogenesis, and inflammatory diseases (PMID: 17503783).