Hepsin Polyklonaler Antikörper

Hepsin Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 51060-1-PBS

Synonyme

Hpn, AI788568, EC:3.4.21.106, Serine protease hepsin non-catalytic chain, TMPRSS 1

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  WB analysis of human liver using 51060-1-Ig (same clone as 51060-1-PBS)

  human liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51060-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse liver using 51060-1-Ig (same clone as 51060-1-PBS)

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51060-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

51060-1-PBS bindet in WB, Indirect ELISA Hepsin und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: hepsin
• Berechnetes Molekulargewicht: 47 kDa
• Beobachtetes Molekulargewicht: 28 kDa
• GenBank-Zugangsnummer: BC138809
• Gene symbol: Hepsin
• Gene ID (NCBI): 15451
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Hepsin is a type II transmembrane serine protease. It is primarily expressed in the liver but has also been detected in other tissues, including the prostate, kidney, and pancreas. Hepsin plays a crucial role in various physiological processes, such as cell growth, extracellular matrix remodeling, and tissue homeostasis. Notably, Hepsin has been implicated in cancer progression, particularly in prostate cancer, where its overexpression is associated with tumor metastasis and poor prognosis (PMID: 15324701, PMID: 18726901). Hepsin has been identified as a peptide of approximately 45 kDa representing the intact protein, and a fragment of about 28 kDa representing the cleaved extracellular domain (PMID: 19302215, PMID: 21734266).