Phospho-Histone H2A.X (Ser139) Rekombinanter Antikörper
Phospho-Histone H2A.X (Ser139) Rekombinant Antikörper für WB, IHC, IF/ICC, FC (Intra), Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus, Ratte
Anwendung
WB, IHC, IF/ICC, FC (Intra), Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
5N19
Kat-Nr. : 83307-2-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
83307-2-PBS bindet in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA Phospho-Histone H2A.X (Ser139) und zeigt Reaktivität mit human, Maus, Ratten
Getestete Reaktivität | human, Maus, Ratte |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | Peptid |
Vollständiger Name | H2A histone family, member X |
Berechnetes Molekulargewicht | 15 kDa |
Beobachtetes Molekulargewicht | 15 kDa |
GenBank-Zugangsnummer | BC013416 |
Gene symbol | Histone H2A.X |
Gene ID (NCBI) | 3014 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein A purfication |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
The histone variant H2AX is a major component of the DNA damage response (DDR), especially functioning in amplifying DNA damage signals. In response to DNA double-strand breaks (DSBs), H2AX is instantaneously phosphorylated at Ser139 (a form called cH2AX) by the kinases ATM and ATR. The phosphorylation of H2AX at Ser139, resulting in the formation of gamma-H2AX puncta in the nuclei, is an early event in the cellular response to DNA damage. Therefore, phospho-Histone H2A. X (Ser139) is also known as γH2AX. The phosphorylation site of H2AX, Ser139, has also been described as Ser140 in other literature, and they recognize the same amino acid site. (PMID: 22908299, PMID: 30106130, PMID:22941631)