Phospho-Histone H2A.X (Ser139) Rekombinanter Antikörper

Phospho-Histone H2A.X (Ser139) Rekombinant Antikörper für WB, IHC, IF/ICC, FC (Intra), Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, IF/ICC, FC (Intra), Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

5N19

Kat-Nr. : 83307-2-PBS

Synonyme

H2A.X (Ser139), H2A.X P-S139, H2A.X Ser139, H2A.XS139, H2A.XS139Ph



Geprüfte Anwendungen

Produktinformation

83307-2-PBS bindet in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA Phospho-Histone H2A.X (Ser139) und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name H2A histone family, member X
Berechnetes Molekulargewicht 15 kDa
Beobachtetes Molekulargewicht15 kDa
GenBank-ZugangsnummerBC013416
Gene symbol Histone H2A.X
Gene ID (NCBI) 3014
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The histone variant H2AX is a major component of the DNA damage response (DDR), especially functioning in amplifying DNA damage signals. In response to DNA double-strand breaks (DSBs), H2AX is instantaneously phosphorylated at Ser139 (a form called cH2AX) by the kinases ATM and ATR. The phosphorylation of H2AX at Ser139, resulting in the formation of gamma-H2AX puncta in the nuclei, is an early event in the cellular response to DNA damage. Therefore, phospho-Histone H2A. X (Ser139) is also known as γH2AX. The phosphorylation site of H2AX, Ser139, has also been described as Ser140 in other literature, and they recognize the same amino acid site. (PMID: 22908299, PMID: 30106130, PMID:22941631)