Hepsin Polyklonaler Antikörper

Hepsin Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 51060-1-Ig

Synonyme

Hpn, AI788568, EC:3.4.21.106, Serine protease hepsin non-catalytic chain, TMPRSS 1

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  WB analysis of human liver using 51060-1-Ig

  human liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse liver using 51060-1-Ig

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 51060-1-Ig (Hepsin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: humanes Lebergewebe, Mauslebergewebe

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

51060-1-Ig bindet in WB, ELISA Hepsin und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: hepsin
• Berechnetes Molekulargewicht: 47 kDa
• Beobachtetes Molekulargewicht: 28 kDa
• GenBank-Zugangsnummer: BC138809
• Gene symbol: Hepsin
• Gene ID (NCBI): 15451
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Hepsin is a type II transmembrane serine protease. It is primarily expressed in the liver but has also been detected in other tissues, including the prostate, kidney, and pancreas. Hepsin plays a crucial role in various physiological processes, such as cell growth, extracellular matrix remodeling, and tissue homeostasis. Notably, Hepsin has been implicated in cancer progression, particularly in prostate cancer, where its overexpression is associated with tumor metastasis and poor prognosis (PMID: 15324701, PMID: 18726901). Hepsin has been identified as a peptide of approximately 45 kDa representing the intact protein, and a fragment of about 28 kDa representing the cleaved extracellular domain (PMID: 19302215, PMID: 21734266).