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ICAM-1/CD54 Rekombinanter Antikörper

ICAM-1/CD54 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Ratte

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240725C2

Kat-Nr. : 98060-1-PBS

Synonyme

CD54, ICAM-1, ICAM-12, Icam1, 240725C2

Filter:
  • Flow cytometry (FC) experiment of rat splenocytes cells using Anti-Rat ICAM-1/CD54 Rabbit Recombinant Antibody (98060-1-RR)

    FC experiment of rat splenocytes using 98060-1-RR (same clone as 98060-1-PBS)

    1x10^6 rat splenocytes were surface stained with 0.25 ug Anti-Rat ICAM-1/CD54 Rabbit Recombinant Antibody (98060-1-RR, Clone:240725C2) (red) or isotype control (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were not fixed. This data was developed using the same antibody clone with 98060-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98060-1-RR

    Affinity and Kinetic Characterization of 98060-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98060-1-RR against Mouse ICAM-1/CD54 were performed. The affinity constant is 0.347 nM.

Geprüfte Anwendungen

Produktinformation

98060-1-PBS bindet in FC ICAM-1/CD54 und zeigt Reaktivität mit Ratten

Getestete Reaktivität Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name intercellular adhesion molecule 1
Berechnetes Molekulargewicht60 kDa
GenBank-ZugangsnummerNM_012967.1
Gene symbol Icam1
Gene ID (NCBI) 25464
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

ICAM-1 (CD54) is a transmembrane glycoprotein of the immunoglobulin superfamily and is critical for the firm attachment and transmigration of leukocytes out of blood vessels and into tissues (PMID: 19307690). ICAM-1 is expressed by several cell types, typically on endothelial cells and cells of the immune system, and its expression can be up-regulated by various stimuli, including TNF-α, INF-γ, IL-1 and thrombin (PMID: 3086451; 9694714; 15979056). It is a ligand for LFA-1 and Mac-1, serves as a receptor for rhinovirus, and is one of several receptors used by Plasmodium falciparum (PMID: 2566624; 2538244; 2475784).