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ICMT Polyklonaler Antikörper

ICMT Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 17511-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using ICMT Polyclonal antibody (17511-1-AP)

    WB analysis using 17511-1-AP (same clone as 17511-1-PBS)

    Jurkat cells lysates were subjected to SDS PAGE followed by western blot with 17511-1-AP (ICMT antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17511-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

17511-1-PBS bindet in WB, Indirect ELISA ICMT und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen Peptid
Vollständiger Name isoprenylcysteine carboxyl methyltransferase
Berechnetes Molekulargewicht 32 kDa
Beobachtetes Molekulargewicht 32-34 kDa
GenBank-ZugangsnummerNM_012405
Gene symbol ICMT
Gene ID (NCBI) 23463
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Isoprenylcysteine carboxylmethyltransferase (ICMT), also known as PCCMT, is a multi-spanning endoplasmic reticulum integral membrane protein conserved among eukaryotic organisms. Methylation by ICMT is important for partitioning of CAAX proteins into lipid membranes as this modification neutralizes the negative charge on the carboxylate and increases the hydrophobicity of the modified protein (PMID: 25059662). Homozygous gene knockout of PPMT interferes with localization of K-Ras to the plasma membrane in mammalian cells and leads to the death of mouse embryos during gestation (PMID: 12141948).