ICOS/CD278 Rekombinanter Antikörper

ICOS/CD278 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

PE Fluorescent Dye

CloneNo.

241770G11

Kat-Nr. : PE-FcA98214

Synonyme

ICOS, Activation-inducible lymphocyte immunomediatory molecule, AILIM, CD278, CVID1

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  FC experiment of human PBMCs using PE-FcA98214

  1x10^6 untreated or PHA-treated or human PBMCs were surface stained with 5 ul PE Anti-Human ICOS/CD278 Rabbit RecAb (PE-FcA98214, Clone: 241770G11) and FcZero-rAb™ APC Anti-Human CD3 (UCHT1) Rabbit IgG Recombinant Antibody (APC-FcA65570, Clone: UCHT1). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: PHA treated human PBMCs

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

PE-FcA98214 bindet in FC ICOS/CD278 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: ICOS/CD278 fusion protein Eg1642
• Vollständiger Name: inducible T-cell co-stimulator
• Berechnetes Molekulargewicht: 199 aa, 23 kDa
• GenBank-Zugangsnummer: BC028210
• Gene symbol: ICOS
• Gene ID (NCBI): 29851
• Konjugation: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

Inducible T cell co-stimulator (ICOS) is related to the CD28 superfamily and is highly expressed on activated T cells as well as regulatory T cells and is crucial for the survival and function of T cells, Th2 cell differentiation, and lung inflammatory responses. Binding ICOS to ICOS-ligand (ICOS-L) activates a cascade of intracellular signaling molecules that prevent apoptosis and lead to the production of cytokines such as IL-4 and IL-13.