ICOSLG/B7-H2/CD275 Rekombinanter Antikörper

ICOSLG/B7-H2/CD275 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242241C8

Kat-Nr. : 98358-1-PBS

Synonyme

B7H2, ICOSLG, B7 H2, B7-like protein Gl50, B7-related protein 1

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  FC experiment of human monocyte-derived mature dendritic cells using 98358-1-RR (same clone as 98358-1-PBS)

  1x10^6 human monocyte-derived mature dendritic cells were surface stained with 0.25 ug Anti-Human ICOSLG/B7-H2/CD275 Rabbit RecAb (98358-1-RR, Clone: 242241C8) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98358-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98358-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98358-1-RR against Human ICOSLG/B7-H2/CD275 were performed. The affinity constant is 10.4 nM.

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Geprüfte Anwendungen

Produktinformation

98358-1-PBS bindet in FC ICOSLG/B7-H2/CD275 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: ICOSLG/B7-H2/CD275 fusion protein Eg0008
• Vollständiger Name: inducible T-cell co-stimulator ligand
• Berechnetes Molekulargewicht: 33 kDa, 34 kDa
• GenBank-Zugangsnummer: BC064637
• Gene symbol: ICOSLG
• Gene ID (NCBI): 23308
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

ICOSLG, also known as B7H2 or GL50, is a type I transmembrane glycoprotein belonging to the B7 ligand family. ICOSLG is extensively expressed on professional antigen-presenting cells including B cells, macrophages, and dendritic cells, as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells (PMID: 33756276; 35800767). It is a specific ligand for the T-cell-specific cell surface receptor ICOS and acts as a co-stimulatory molecule (PMID: 11023515; 11007762). The interaction of ICOSLG and ICOS plays important roles in the activation, proliferation, differentiation, and cytokine production of T cells as well as in the antibody secretion from B cells during secondary immune responses (PMID: 21851236).