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IDH2 Monoklonaler Antikörper

IDH2 Monoklonal Antikörper für WB, FC (Intra), Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, FC (Intra), Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1F10A10

Kat-Nr. : 66918-1-PBS

Synonyme

IDHM, IDH 2, ICD-M, ICD M, EC:1.1.1.42



Geprüfte Anwendungen

Produktinformation

66918-1-PBS bindet in WB, FC (Intra), Indirect ELISA IDH2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen IDH2 fusion protein Ag8950
Vollständiger Name isocitrate dehydrogenase 2 (NADP+), mitochondrial
Berechnetes Molekulargewicht 452 aa, 51 kDa
Beobachtetes Molekulargewicht 41-47 kDa
GenBank-ZugangsnummerBC009244
Gene symbol IDH2
Gene ID (NCBI) 3418
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IDH2, also named as IDP and ICD-M, belongs to the isocitrate and isopropylmalate dehydrogenases family. It plays a role in intermediary metabolism and energy production. IDH2 is a mitochondrial NADP-dependent isocitrate dehydrogenase that catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH. It may tightly associate or interact with the pyruvate dehydrogenase complex. IDH1 and IDH2 mutations could also contribute to tumorigenesis and cancer progression through increased mutagenesis. IDH2 has 2 isoforms with the MW of 51 kDa and 45 kDa, and the mature form is about 47 kDa and 41 kDa with the N-terminal transit peptide cleaved.