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IDH2 Monoklonaler Antikörper
IDH2 Monoklonal Antikörper für WB, FC (Intra), Indirect ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
WB, FC (Intra), Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
1F10A10
Kat-Nr. : 66918-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
66918-1-PBS bindet in WB, FC (Intra), Indirect ELISA IDH2 und zeigt Reaktivität mit human
| Getestete Reaktivität | human | 
| Wirt / Isotyp | Maus / IgG1 | 
| Klonalität | Monoklonal | 
| Typ | Antikörper | 
| Immunogen | IDH2 fusion protein Ag8950 | 
| Vollständiger Name | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 
| Berechnetes Molekulargewicht | 452 aa, 51 kDa | 
| Beobachtetes Molekulargewicht | 41-47 kDa | 
| GenBank-Zugangsnummer | BC009244 | 
| Gene symbol | IDH2 | 
| Gene ID (NCBI) | 3418 | 
| Konjugation | Unkonjugiert | 
| Form | Liquid | 
| Reinigungsmethode | Protein-G-Reinigung | 
| Lagerungspuffer | PBS only | 
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. | 
Hintergrundinformationen
IDH2, also named as IDP and ICD-M, belongs to the isocitrate and isopropylmalate dehydrogenases family. It plays a role in intermediary metabolism and energy production. IDH2 is a mitochondrial NADP-dependent isocitrate dehydrogenase that catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH. It may tightly associate or interact with the pyruvate dehydrogenase complex. IDH1 and IDH2 mutations could also contribute to tumorigenesis and cancer progression through increased mutagenesis. IDH2 has 2 isoforms with the MW of 51 kDa and 45 kDa, and the mature form is about 47 kDa and 41 kDa with the N-terminal transit peptide cleaved.









