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IDS Rekombinanter Antikörper

IDS Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242054A7

Kat-Nr. : 84623-6-PBS

Synonyme

Iduronate 2-sulfatase 42 kDa chain, Iduronate 2-sulfatase 14 kDa chain, Iduronate 2-sulfatase, EC:3.1.6.13, Alpha-L-iduronate sulfate sulfatase

Filter:
  • Western Blot (WB) analysis of various lysates using IDS Recombinant antibody (84623-6-RR)

    WB analysis using 84623-6-RR (same clone as 84623-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84623-6-RR (IDS antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84623-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84623-6-RR

    Affinity and Kinetic Characterization of 84623-6-RR

    Biolayer interferometry (BLl) kinetic assays of 84623-6-RR against Human IDS were performed. The affinity constant is 11.8 nM.

Geprüfte Anwendungen

Produktinformation

84623-6-PBS bindet in WB, Indirect ELISA IDS und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen IDS fusion protein Ag31132
Vollständiger Name iduronate 2-sulfatase
Berechnetes Molekulargewicht312aa,35 kDa; 550aa,62 kDa
Beobachtetes Molekulargewicht42 kDa
GenBank-ZugangsnummerBC006170
Gene symbol IDS
Gene ID (NCBI) 3423
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Iduronate 2-sulfatase (IDS) is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations causing IDS deficiency in humans result in the lysosomal storage of these glycosaminoglycans and Hunter syndrome, an X chromosome-linked disease. IDS is synthesized as two precursor forms of 76 and 90 kDa that are converted, through a 62 kDa intermediate, to mature polypeptides due to an internal proteolytic cleavage (PMID: 10838181).