IFN-gamma Rekombinanter Antikörper
IFN-gamma Rekombinant Antikörper für FC (Intra)
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
FC (Intra)
Konjugation
Unkonjugiert
CloneNo.
241390B10
Kat-Nr. : 98187-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
98187-1-PBS bindet in FC (Intra) IFN-gamma und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | IFN-gamma fusion protein Eg0004 |
Vollständiger Name | IFN gamma |
Berechnetes Molekulargewicht | 166 aa, 19 kDa |
GenBank-Zugangsnummer | BC070256 |
Gene symbol | IFNG |
Gene ID (NCBI) | 3458 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein A purfication |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. |
Hintergrundinformationen
Interferon gamma (IFN γ), is a type II interferon that provides immunity against bacterial, viral and protozoan infections. In its active form, IFN γ is a glycosylated, non-covalently linked homodimer of 29-32 kDa subunits. It is produced by a number of immune cell types including natural killer cells, natural killer T cells, and effector lymphocyte T cells following antigenic and inflammatory triggers. The IFN γ dimer binds to its cognate receptor which has two subunits: IFN-γR1 which is the ligand-binding chain (α chain) and IFN-γR2, the signal-transducing chain (β chain). Binding to the receptor activates the JAK/STAT pathway which in turn activates IFN γ responsive genes. While IFN γ can inhibit viral replication, it also works as an immune-modulator and immune-stimulator by increasing surface expression of class I MHC proteins. (PMID: 19268625; 10688427)