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IGF1R/CD221 Rekombinanter Antikörper

IGF1R/CD221 Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

240801A3

Kat-Nr. : 83873-6-PBS

Synonyme

IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR

Filter:
  • Western Blot (WB) analysis of various lysates using IGF1R/CD221 Recombinant antibody (83873-6-RR)

    WB analysis using 83873-6-RR (same clone as 83873-6-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83873-6-RR (IGF1R antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83873-6-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

83873-6-PBS bindet in WB, ELISA IGF1R/CD221 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name IGF I receptor
Berechnetes Molekulargewicht 155 kDa
Beobachtetes Molekulargewicht100 kDa
GenBank-ZugangsnummerNM_000875
Gene symbol IGF1R
Gene ID (NCBI) 3480
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is translated as ~220 kDa pro-receptors (PMID: 33969359). IGF1R is a heterotetrameric receptor, composed of two alpha subunits (~130 kDa) and two beta subunits (~100-120 kDa) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.