IGF1R/CD221 Rekombinanter Antikörper

IGF1R/CD221 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

APC Fluorescent Dye

CloneNo.

241679A6

Kat-Nr. : APC-FcA98144

Synonyme

IGF 1 receptor, IGF1R, IGF-I receptor, IGFIR, IGFR

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  FC experiment of human peripheral blood leukocyte using APC-FcA98144

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul APC Anti-Human IGF1R/CD221 Rabbit RecAb (APC-FcA98144, Clone: 241679A6) or APC Rabbit IgG Isotype Control RecAb (APC-FcA98136, Clone: 240953C9). Cells were not fixed.

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  FC experiment of human peripheral blood leukocyte using APC-FcA98144

  1x10^6 human peripheral blood leukocytes were surface stained with 5 ul APC Anti-Human IGF1R/CD221 Rabbit RecAb (APC-FcA98144, Clone: 241679A6) (red), or APC Rabbit IgG Isotype Control RecAb (APC-FcA98136, Clone: 240953C9) (blue). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: human peripheral blood leukocyte

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

APC-FcA98144 bindet in FC IGF1R/CD221 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: IGF I receptor
• Berechnetes Molekulargewicht: 1367 aa, 155 kDa
• GenBank-Zugangsnummer: BC113612
• Gene symbol: IGF1R
• Gene ID (NCBI): 3480
• Konjugation: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is translated as ~220 kDa pro-receptors (PMID: 33969359). IGF1R is a heterotetrameric receptor, composed of two alpha subunits (~130 kDa) and two beta subunits (~100-120 kDa) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds.