• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

IGFBP1 Polyklonaler Antikörper

IGFBP1 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13981-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using IGFBP1 Polyclonal antibody (13981-1-AP)

    WB analysis using 13981-1-AP (same clone as 13981-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13981-1-AP (IGFBP1 antibody) at dilution of 1:12000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13981-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using IGFBP1 Polyclonal antibody (13981-1-AP)

    IHC staining of human lung cancer using 13981-1-AP (same clone as 13981-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 13981-1-AP (IGFBP1 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13981-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

13981-1-PBS bindet in WB, IHC, Indirect ELISA IGFBP1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen IGFBP1 fusion protein Ag5026
Vollständiger Name IGF binding protein 1
Berechnetes Molekulargewicht 28 kDa
Beobachtetes Molekulargewicht 28-35 kDa
GenBank-ZugangsnummerBC057806
Gene symbol IGFBP1
Gene ID (NCBI) 3484
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IGF-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and INS resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome.