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IGFBP6 Rekombinanter Antikörper

IGFBP6 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241724H5

Kat-Nr. : 84364-5-PBS

Synonyme

IGF-binding protein 6, IGF binding protein 6, IBP-6, IBP6, IBP 6

Filter:
  • Western Blot (WB) analysis of human testis tissue using IGFBP6 Recombinant antibody (84364-5-RR)

    WB analysis of human testis using 84364-5-RR (same clone as 84364-5-PBS)

    human testis tissue were subjected to SDS PAGE followed by western blot with 84364-5-RR (IGFBP6 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84364-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84364-5-RR

    Affinity and Kinetic Characterization of 84364-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84364-5-RR against Human IGFBP6 were performed. The affinity constant is 0.259 nM.

Geprüfte Anwendungen

Produktinformation

84364-5-PBS bindet in WB, Indirect ELISA IGFBP6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name insulin-like growth factor binding protein 6
Berechnetes Molekulargewicht 25 kDa
Beobachtetes Molekulargewicht34 kDa
GenBank-ZugangsnummerBC011708
Gene symbol IGFBP6
Gene ID (NCBI) 3489
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Insulin-like growth factor (IGF) binding protein (IGFBP6), a 240 amino acid protein, contains an IGFBP N-terminal domain and a thyroglobulin type-1 domain. It modulates the activity of IGF and shows independent effects of IGF, such as growth inhibition and apoptosis. It can decrease the proliferation and survival of cancer cells such as lung cancer cells and naso-pharyngeal cancer cells. IGFBP-6 is distinctive for its 50-fold higher binding affinity for IGF-II over IGF-I and this specificity makes it an attractive potential therapeutic candidate for IGF-II-dependent pediatric malignancies such as rhabdomyosarcoma (RMS). In addition, it was found that IGFBP6 can promote the migration of RMS cells in an IGF-independent manner, and MAPK pathways were involved in this process. Further study reported that IGFBP6 is one of most highly expressed proteins in varicose vein tissues and is involved in the proliferation of vascular smooth muscle cells (VSMCs), which may provide insights into the underlying pathogenesis of varicose vein.