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IL-10 Monoklonaler Antikörper

IL-10 Monoklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

8E4B6

Kat-Nr. : 60269-1-PBS

Synonyme

IL-10,IL10, 8E4B6, CSIF, IL 10, IL10



Geprüfte Anwendungen

Produktinformation

60269-1-PBS bindet in WB, IF/ICC, Indirect ELISA IL-10 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2b
Klonalität Monoklonal
Typ Antikörper
Immunogen IL-10 fusion protein Ag14870
Vollständiger Name interleukin 10
Berechnetes Molekulargewicht 21 kDa
Beobachtetes Molekulargewicht 22 kDa
GenBank-ZugangsnummerBC104252
Gene symbol IL-10
Gene ID (NCBI) 3586
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.