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IL-10 Monoklonaler Antikörper
IL-10 Monoklonal Antikörper für WB, IF/ICC, Indirect ELISA
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human
Anwendung
WB, IF/ICC, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
8E4B6
Kat-Nr. : 60269-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60269-1-PBS bindet in WB, IF/ICC, Indirect ELISA IL-10 und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Maus / IgG2b |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | IL-10 fusion protein Ag14870 |
Vollständiger Name | interleukin 10 |
Berechnetes Molekulargewicht | 21 kDa |
Beobachtetes Molekulargewicht | 22 kDa |
GenBank-Zugangsnummer | BC104252 |
Gene symbol | IL-10 |
Gene ID (NCBI) | 3586 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.