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IL-10RA Rekombinanter Antikörper

IL-10RA Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241833D5

Kat-Nr. : 84428-3-PBS

Synonyme

IL10RA, IL 10R subunit alpha, IL 10R subunit 1, IL 10 receptor subunit alpha, HIL 10R

Filter:
  • Western Blot (WB) analysis of various lysates using IL-10RA Recombinant antibody (84428-3-RR)

    WB analysis using 84428-3-RR (same clone as 84428-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84428-3-RR (IL-10RA antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84428-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84428-3-PBS bindet in WB, Indirect ELISA IL-10RA und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen FusionProtein
Vollständiger Name interleukin 10 receptor, alpha
Berechnetes Molekulargewicht 578 aa, 63 kDa
Beobachtetes Molekulargewicht90 kDa
GenBank-ZugangsnummerBC028082
Gene symbol IL-10RA
Gene ID (NCBI) 3587
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in maintaining immune system balance. IL-10 signals through a receptor complex consisting of two molecules of the IL-10R alpha-chain (IL-10RA) and two molecules of the accessory IL-10R beta-chain (IL-10RB) (PMID: 22236434). IL-10RA and IL-10RB are members of the type II cytokine receptor family. IL-10RA, also known as IL-10R1 or CD210, is expressed on most hematopoietic cells at a basal level but is upregulated by various cells upon activation (PMID: 24507158). IL-10RA serves as the ligand-binding subunit of the receptor complex. Upon binding of IL-10 to the IL-10R complex, the kinases JAK1 and TYK2 are activated and catalyze the phosphorylation of IL-10RA at specific intracellular tyrosine residues, leading to the recruitment and subsequent phosphorylation of STAT3 (PMID: 11244051; 10433356).