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IL-12/IL-23 p40 Monoklonaler Antikörper

IL-12/IL-23 p40 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

Hausschwein, human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

4B2A8

Kat-Nr. : 66288-1-PBS

Synonyme

IL12B, IL 12B, IL 12 subunit p40, IL 12 P40, Cytotoxic lymphocyte maturation factor 40 kDa subunit

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  • Western Blot (WB) analysis of human liver tissue using IL-12/IL-23 p40 Monoclonal antibody (66288-1-Ig)

    WB analysis of human liver using 66288-1-Ig (same clone as 66288-1-PBS)

    human liver tissue were subjected to SDS PAGE followed by western blot with 66288-1-Ig (IL12B Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66288-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

66288-1-PBS bindet in WB, Indirect ELISA IL-12/IL-23 p40 und zeigt Reaktivität mit Hausschwein, human

Getestete Reaktivität Hausschwein, human
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen IL-12/IL-23 p40 fusion protein Ag21429
Vollständiger Name interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Berechnetes Molekulargewicht 328 aa, 37 kDa
Beobachtetes Molekulargewicht 37 kDa
GenBank-ZugangsnummerBC067498
Gene symbol IL12B
Gene ID (NCBI) 3593
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).