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IL-12/IL-23 p40 Rekombinanter Antikörper

IL-12/IL-23 p40 Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241600B3

Kat-Nr. : 83008-7-PBS

Synonyme

IL12B, 241600B3, CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL 12 P40

Filter:
  • Immunofluorescence (IF) / fluorescent staining of MOLT-4 cells using IL-12/IL-23 p40 Recombinant antibody (83008-7-RR)

    IF Staining of MOLT-4 using 83008-7-RR (same clone as 83008-7-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MOLT-4 cells using IL12B antibody (83008-7-RR, Clone: 241600B3 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 83008-7-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

83008-7-PBS bindet in IF/ICC, Indirect ELISA IL-12/IL-23 p40 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen IL-12/IL-23 p40 fusion protein Eg0431
Vollständiger Name interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Berechnetes Molekulargewicht 328 aa, 37 kDa
GenBank-ZugangsnummerBC067498
Gene symbol IL12B
Gene ID (NCBI) 3593
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).