IL-12RB1/CD212 Rekombinanter Antikörper

IL-12RB1/CD212 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241661H1

Kat-Nr. : 98149-1-PBS

Synonyme

IL12RB1, IL-12 receptor beta component, IL 12RB1, IL 12R subunit beta 1, IL 12R beta 1

---

• 

  FC experiment of human PBMCs using 98149-1-RR (same clone as 98149-1-PBS)

  1x10^6 anti-CD3/CD28 treated human PBMCs were surface stained with 0.25 ug Anti-Human IL-12RB1/CD212 Rabbit Recombinant Antibody (98149-1-RR, Clone: 241661H1) (red) or Isotype Control (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human IL-12RB1/CD212 Rabbit Recombinant Antibody (98149-1-RR, Clone: 241661H1) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98149-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98149-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98149-1-RR against Human IL-12RB1/CD212 were performed. The affinity constant is 2.2 nM.

---

Geprüfte Anwendungen

Produktinformation

98149-1-PBS bindet in FC IL-12RB1/CD212 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: interleukin 12 receptor, beta 1
• Berechnetes Molekulargewicht: 662 aa, 73 kDa
• GenBank-Zugangsnummer: BC029121
• Gene symbol: IL12RB1
• Gene ID (NCBI): 3594
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Interleukin-12 receptor subunit beta-1 (IL-12RB1), also named as CD212, is a 662 amino acid protein, which contains 5 fibronectin type-III domains and belongs to the type I cytokine receptor family. IL-12RB1 localizes in the membrane and functions as an interleukin receptor which binds IL-12 with low affinity and is involved in IL-12 transduction. Associated with IL-12RB2 it forms a functional, high affinity receptor for IL-12. It can also associate with IL23R to form the interleukin-23 receptor which functions in IL-23 signal transduction probably through activation of the Jak-Stat signaling cascade.