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IL-13Ra1/CD213a1 Polyklonaler Antikörper

IL-13Ra1/CD213a1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 27916-1-PBS

Synonyme

IL13RA1, Cancer/testis antigen 19, CD213A1, CT19, IL 13 receptor subunit alpha 1

Filter:
  • Western Blot (WB) analysis of various lysates using IL-13Ra1/CD213a1 Polyclonal antibody (27916-1-AP)

    WB analysis using 27916-1-AP (same clone as 27916-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27916-1-AP (IL-13RA1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27916-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

27916-1-PBS bindet in WB, Indirect ELISA IL-13Ra1/CD213a1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen IL-13Ra1/CD213a1 fusion protein Ag25542
Vollständiger Name interleukin 13 receptor, alpha 1
Berechnetes Molekulargewicht 49 kDa
Beobachtetes Molekulargewicht70 kDa
GenBank-ZugangsnummerBC009960
Gene symbol IL-13Rα1
Gene ID (NCBI) 3597
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-13 is an immunoregulatory cytokine secreted predominantly by activated T-helper 2 (Th2) cells and performs multiple functions through a complex receptor system comprised of IL-4Rα and two IL-13 binding proteins, IL-13Rα1 and IL-13Rα2 (PMID: 12704343). IL-13Rα1 is a 65- to 70-kd glycosylated transmembrane protein (PMID: 10856136; 9723655). IL-13Rα1 is expressed on a wide range of cells including B cells, monocytes, macrophages, basophils, mast cells, and endothelial cells (PMID: 10856136; 31866859). IL-13 binding to the IL-4Rα/IL-13Rα1 complex leads to activation of JAK1, JAK2, and TYK2 and subsequent phosphorylation of STAT6 and STAT3 (PMID: 31866859).