IL-13Ra1/CD213a1 Rekombinanter Antikörper

IL-13Ra1/CD213a1 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

241834A1

Kat-Nr. : 98216-1-RR

Synonyme

IL13RA1, IL 13R alpha 1, IL 13 receptor subunit alpha 1, CT19, CD213A1

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  FC experiment of MCF-7 using 98216-1-RR

  1x10^6 MCF-7 cells (left) or Jurkat cells (right) were surface stained with 0.125 ug Anti-Human IL-13Ra1/CD213a1 Rabbit Recombinant Antibody (98216-1-RR, Clone: 241834A1) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98216-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98216-1-RR against Human IL-13Ra1/CD213a1 were performed. The affinity constant is below 1 pM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: MCF-7-Zellen

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98216-1-RR bindet in FC IL-13Ra1/CD213a1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: interleukin 13 receptor, alpha 1
• Berechnetes Molekulargewicht: 49 kDa
• GenBank-Zugangsnummer: BC009960
• Gene symbol: IL-13Rα1
• Gene ID (NCBI): 3597
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

IL-13 is an immunoregulatory cytokine secreted predominantly by activated T-helper 2 (Th2) cells and performs multiple functions through a complex receptor system comprised of IL-4Rα and two IL-13 binding proteins, IL-13Rα1 and IL-13Rα2 (PMID: 12704343). IL-13Rα1 is a glycosylated transmembrane protein (PMID: 10856136; 9723655). IL-13Rα1 is expressed on a wide range of cells including B cells, monocytes, macrophages, basophils, mast cells, and endothelial cells (PMID: 10856136; 31866859). IL-13 binding to the IL-4Rα/IL-13Rα1 complex leads to activation of JAK1, JAK2, and TYK2 and subsequent phosphorylation of STAT6 and STAT3 (PMID: 31866859).