IL-16 Rekombinanter Antikörper

IL-16 Rekombinant Antikörper für FC (Intra)

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC (Intra)

Konjugation

Unkonjugiert

CloneNo.

250058E6

Kat-Nr. : 98535-1-PBS

Synonyme

Il16, Interleukin-16, Pro-interleukin-16

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  FC experiment of Transfected HEK-293T using 98535-1-RR (same clone as 98535-1-PBS)

  1x10^6 HEK-293T cells or IL-16 transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-16 Rabbit RecAb (98535-1-RR, Clone: 250058E6) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98535-1-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98535-1-RR (same clone as 98535-1-PBS)

  1x10^6 HEK-293T cells or IL-16 transfected HEK-293T cells were intracellularly stained with 0.25 ug Anti-Mouse IL-16 Rabbit RecAb (98535-1-RR, Clone: 250058E6) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98535-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98535-1-PBS bindet in FC (Intra) IL-16 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-16 fusion protein Eg3127
• Vollständiger Name: interleukin 16
• Berechnetes Molekulargewicht: 141 kDa
• GenBank-Zugangsnummer: NM_010551.3
• Gene symbol: Il16
• Gene ID (NCBI): 16170
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. It is mainly produced by T lymphocytes but also by other immune cells, neuronal cells, fibroblasts and epithelial cells. The signaling process of this cytokine is mediated by CD4. IL-16 induces chemotaxis of CD4+ cells such as lymphocytes, eosinophils, and dendritic cells by ligating CD4 directly at a site distinct from other ligands. Among its multiple functions, IL-16 is a T cell chemoattractant involved in T helper cell inflammatory responses and the regulation of both T cell growth, and responsiveness to regulatory cytokines. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control.