• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

IL-17A Rekombinanter Antikörper

IL-17A Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

230038B1

Kat-Nr. : 82905-1-PBS

Synonyme

Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A

Filter:
  • Western Blot (WB) analysis of EL-4 cells using IL-17A Recombinant antibody (82905-1-RR)

    WB analysis of EL-4 using 82905-1-RR (same clone as 82905-1-PBS)

    PMA, Ionomycin and Brefeldin A treated EL-4 cells were subjected to SDS PAGE followed by western blot with 82905-1-RR (IL-17A antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82905-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 82905-1-RR

    Affinity and Kinetic Characterization of 82905-1-RR

    Biolayer interferometry (BLl) kinetic assays of 82905-1-RR against Mouse IL-17A were performed. The affinity constant is 7.59 nM.

Geprüfte Anwendungen

Produktinformation

82905-1-PBS bindet in WB, Indirect ELISA IL-17A und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Rekombinantes Protein
Vollständiger Name interleukin 17A
Berechnetes Molekulargewicht17 kDa
Beobachtetes Molekulargewicht14 kDa, 17 kDa
GenBank-ZugangsnummerNM-010552
Gene symbol Il17a
Gene ID (NCBI) 16171
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.