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IL-17B Polyklonaler Antikörper

IL-17B Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 24495-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using IL-17B Polyclonal antibody (24495-1-AP)

    WB analysis using 24495-1-AP (same clone as 24495-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24495-1-AP (IL-17B antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24495-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

24495-1-PBS bindet in WB, Indirect ELISA IL-17B und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen IL-17B fusion protein Ag21453
Vollständiger Name interleukin 17B
Berechnetes Molekulargewicht 180 aa, 20 kDa
Beobachtetes Molekulargewicht24 kDa
GenBank-ZugangsnummerBC113925
Gene symbol IL-17B
Gene ID (NCBI) 27190
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The interleukin (IL)-17 superfamily, a relatively new family of cytokines, consists of six ligands (from IL-17A to IL-17F), which bind to five receptor subtypes (from IL-17RA to IL-17RE) and induce downstream signaling. IL-17B was originally described as increased during intestinal inflammation. Moreover, it stimulates TNF-α and IL-1β production by the human monocytic leukemia THP-1 cells and promotes neutrophil migration upon intraperitoneal administration, suggesting a pro-inflammatory role. More recent findings strongly suggest a role for the IL-17B/IL-17RB pathway in tumorigenesis.