IL-17F Monoklonaler Antikörper
IL-17F Monoklonal Antikörper für WB, Indirect ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
WB, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
6H5F10
Kat-Nr. : 60245-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
60245-1-PBS bindet in WB, Indirect ELISA IL-17F und zeigt Reaktivität mit human
| Getestete Reaktivität | human | 
| Wirt / Isotyp | Maus / IgG1 | 
| Klonalität | Monoklonal | 
| Typ | Antikörper | 
| Immunogen | IL-17F fusion protein Ag16310 | 
| Vollständiger Name | interleukin 17F | 
| Berechnetes Molekulargewicht | 163 aa, 18 kDa | 
| Beobachtetes Molekulargewicht | 37 kDa | 
| GenBank-Zugangsnummer | BC070124 | 
| Gene symbol | IL-17F | 
| Gene ID (NCBI) | 112744 | 
| Konjugation | Unkonjugiert | 
| Form | Liquid | 
| Reinigungsmethode | Protein-G-Reinigung | 
| Lagerungspuffer | PBS only | 
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. | 
Hintergrundinformationen
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17 family plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. IL-17A is a pro-inflammatory cytokine that also has the capacity to promote angiogenesis and osteoclastogenesis. IL-17F shares the highest homology with IL-17A and signals via a receptor composed by the IL-17RA and IL-17RC subunits. IL-17A and IL-17F can form IL-17A/A or IL-17F/F homodimers, IL-17A/F heterodimers are also formed. IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. IL-17F levels are elevated in sera and lesional psoriatic skin compared to non-lesional tissue. IL-17F also has been implicated in the development of neutrophilic airway inflammation.

