IL-17RB Rekombinanter Antikörper

IL-17RB Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242967D1

Kat-Nr. : 98455-2-PBS

Synonyme

Evi27, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, Il17br

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  FC experiment of Transfected HEK-293T using 98455-2-RR (same clone as 98455-2-PBS)

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone: 242967D1) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98455-2-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98455-2-RR (same clone as 98455-2-PBS)

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone:242967D1) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98455-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98455-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98455-2-RR against Mouse IL-17RB were performed. The affinity constant is 0.697 nM.

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Geprüfte Anwendungen

Produktinformation

98455-2-PBS bindet in FC IL-17RB und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-17RB fusion protein Eg2798
• Vollständiger Name: interleukin 17 receptor B
• Berechnetes Molekulargewicht: 56 kDa
• GenBank-Zugangsnummer: NM_019583.3
• Gene symbol: Il17rb
• Gene ID (NCBI): 50905
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

IL-17RB is a transmembrane protein that belongs to the IL-17 receptor family. IL-17RB has a SEFIR cytoplasmic domain implicated in homotypic dimerization and recruitment of signaling proteins (shared with IL-17RA) and a TRAF6-binding domain (not found in IL-17RA). IL-17RB is expressed in various endocrine tissues and epithelial cells in different organs such as kidney, liver, and mucosal tissues. The IL-17B/IL-17RB pathway is considered as a signaling cascade that promotes cancer cell survival, proliferation and migration. The pro-tumor functions associated with the IL 17B/IL-17RB pathway are diverse and complex because they involve mechanisms that act directly on tumor cells, and also indirect mechanisms that lead to tumor microenvironment remodeling.