IL-17RB Rekombinanter Antikörper

IL-17RB Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242967D1

Kat-Nr. : 98455-2-RR

Synonyme

Evi27, IL-17 receptor B, IL-17 receptor homolog 1, IL-17B receptor, Il17br

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  FC experiment of Transfected HEK-293T using 98455-2-RR

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone: 242967D1) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  FC experiment of Transfected HEK-293T using 98455-2-RR

  1x10^6 HEK-293T cells or IL-17RB transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse IL-17RB Rabbit RecAb (98455-2-RR, Clone:242967D1) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98455-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98455-2-RR against Mouse IL-17RB were performed. The affinity constant is 0.697 nM.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: Transfected HEK-293T cells

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98455-2-RR bindet in FC IL-17RB und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-17RB fusion protein Eg2798
• Vollständiger Name: interleukin 17 receptor B
• Berechnetes Molekulargewicht: 56 kDa
• GenBank-Zugangsnummer: NM_019583.3
• Gene symbol: Il17rb
• Gene ID (NCBI): 50905
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

IL-17RB is a transmembrane protein that belongs to the IL-17 receptor family. IL-17RB has a SEFIR cytoplasmic domain implicated in homotypic dimerization and recruitment of signaling proteins (shared with IL-17RA) and a TRAF6-binding domain (not found in IL-17RA). IL-17RB is expressed in various endocrine tissues and epithelial cells in different organs such as kidney, liver, and mucosal tissues. The IL-17B/IL-17RB pathway is considered as a signaling cascade that promotes cancer cell survival, proliferation and migration. The pro-tumor functions associated with the IL 17B/IL-17RB pathway are diverse and complex because they involve mechanisms that act directly on tumor cells, and also indirect mechanisms that lead to tumor microenvironment remodeling.