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IL-19 Polyklonaler Antikörper

IL-19 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 23705-1-PBS

Synonyme

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  • Immunohistochemistry (IHC) staining of human skin cancer tissue using IL-19 Polyclonal antibody (23705-1-AP)

    IHC staining of human skin cancer using 23705-1-AP (same clone as 23705-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 23705-1-AP (IL-19 antibody at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 23705-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

23705-1-PBS bindet in IHC, Indirect ELISA IL-19 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen IL-19 fusion protein Ag18887
Vollständiger Name interleukin 19
Berechnetes Molekulargewicht 177 aa, 20 kDa
GenBank-ZugangsnummerBC153127
Gene symbol IL-19
Gene ID (NCBI) 29949
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-19, a member of the IL-10 cytokine family (IL-10, -19, -20, -22, -24, -26, -28, and -29), is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-α production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.