IL-19 Polyklonaler Antikörper

IL-19 Polyklonal Antikörper für IHC, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen(1)

Kat-Nr. : 24402-1-AP

Synonyme

IL19, IL 10C, IL 19, interleukin 19, interleukin19

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  IHC staining of human breast cancer using 24402-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 24402-1-AP (IL-19 antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human breast cancer using 24402-1-AP

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 24402-1-AP (IL-19 antibody at dilution of 1:50 (under 40x lens).

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  IHC staining of human skin cancer using 24402-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 24402-1-AP (IL-19 antibody at dilution of 1:50 (under 10x lens).

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  IHC staining of human skin cancer using 24402-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 24402-1-AP (IL-19 antibody at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

• Erfolgreiche Detektion in IHC: humanes Mammakarzinomgewebe, humanes Hautkrebsgewebe; Hinweis: Antigendemaskierung mit TE-Puffer pH 9,0 empfohlen. (*) Wahlweise kann die Antigendemaskierung auch mit Citratpuffer pH 6,0 erfolgen.

Empfohlene Verdünnung

• Immunhistochemie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 1 publications below

Produktinformation

24402-1-AP bindet in WB, IHC, ELISA IL-19 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: IL-19 fusion protein Ag21496
• Vollständiger Name: interleukin 19
• Berechnetes Molekulargewicht: 177 aa, 20 kDa
• GenBank-Zugangsnummer: BC153127
• Gene symbol: IL-19
• Gene ID (NCBI): 29949
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-α production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.

Publikationen

Species	Application	Title
human	WB	Inflamm Res; Interleukin-19 enhances eosinophil infiltration through upregulation of epithelium-derived RANTES expression via the ERK/NF-κB signalling pathway in patients with eosinophilic CRSwNP; Authors - Zizhen Huang