IL-19 Rekombinanter Antikörper

IL-19 Rekombinant Antikörper für FC (Intra)

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC (Intra)

Konjugation

Unkonjugiert

CloneNo.

242880F4

Kat-Nr. : 98431-2-PBS

Synonyme

Il19, Interleukin-19

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  FC experiment of Transfected HEK-293T using 98431-2-RR (same clone as 98431-2-PBS)

  1x10^6 HEK-293T cells (left) or IL-19 transfected HEK-293T cells (right) were intracellularly stained with 0.25 ug Anti-Mouse IL-19 Rabbit RecAb (98431-2-RR, Clone: 242880F4) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98431-2-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98431-2-RR (same clone as 98431-2-PBS)

  1x10^6 HEK-293T cells (left) or IL-19 transfected HEK-293T cells (right) were intracellularly stained with 0.25 ug Anti-Mouse IL-19 Rabbit RecAb (98431-2-RR, Clone: 242880F4) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98431-2-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98431-2-PBS bindet in FC (Intra) IL-19 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-19 fusion protein Eg2844
• Vollständiger Name: interleukin 19
• Berechnetes Molekulargewicht: 20 kDa
• GenBank-Zugangsnummer: NM_001009940.1
• Gene symbol: Il19
• Gene ID (NCBI): 329244
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-α
production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.