IL-1R1 Rekombinanter Antikörper

IL-1R1 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242245A10

Kat-Nr. : 98282-1-PBS

Synonyme

IL1R1, IL 1R 1, EC:3.2.2.6, D2S1473, CD121A

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  FC experiment of HeLa using 98282-1-RR (same clone as 98282-1-PBS)

  1x10^6 HeLa cells (left) or SK-OV-3 cells (right) were surface stained with 0.25 ug Anti-Human IL1R1 Rabbit RecAb (98282-1-RR, Clone: 242245A10) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98282-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98282-1-PBS bindet in FC IL-1R1 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: interleukin 1 receptor, type I
• Berechnetes Molekulargewicht: 65 kDa
• GenBank-Zugangsnummer: NM_000877.4
• Gene symbol: IL1R1
• Gene ID (NCBI): 3554
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

IL-1R1 (IL-1 receptor type 1, also known as p80, IL-1R-alpha or CD121a) is a 80 kDa transmembrane glycoprotein and a member of the interleukin-1 receptor family (PMID: 35163653; 29248002). It is a receptor for IL-1α, IL-1β, and interleukin-1 receptor antagonist (IL-1Ra). IL-1α and IL-1β interact with the extracellular domain of IL-1R1, triggering the recruitment of an accessory receptor, the IL-1RAcP, resulting in a functional receptor complex that initiates IL-1R1 signaling cascades (PMID: 35163653). IL-1Ra competes with active IL-1 and blocks binding to their common activating receptor IL-1R1 and, thus, inhibits IL-1 signaling (PMID: 35332327; 11641511). It has been reported that IL-1R1 may also bind IL-38 (PMID: 29248002). IL-1R1 expression has been found in many cell types including T cells, macrophages, neutrophils, eosinophils, basophils, mast cells, fibroblasts, and endothelial cells.