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IL-1RA Rekombinanter Antikörper

IL-1RA Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241879B3

Kat-Nr. : 84532-4-PBS

Synonyme

IL 1ra, IL1RN, 241879B3, ICIL-1RA, IL 1RN

Filter:
  • Western Blot (WB) analysis of various lysates using IL-1RA Recombinant antibody (84532-4-RR)

    WB analysis using 84532-4-RR (same clone as 84532-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84532-4-RR (IL-1RA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84532-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84532-4-RR

    Affinity and Kinetic Characterization of 84532-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84532-4-RR against Human IL-1RA were performed. The affinity constant is 0.302 nM.

Geprüfte Anwendungen

Produktinformation

84532-4-PBS bindet in WB, Indirect ELISA IL-1RA und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen IL-1RA fusion protein Ag1277
Vollständiger Name interleukin 1 receptor antagonist
Berechnetes Molekulargewicht 20 kDa
Beobachtetes Molekulargewicht16-18 kDa
GenBank-ZugangsnummerBC009745
Gene symbol IL-1RA
Gene ID (NCBI) 3557
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interleukin-1 receptor antagonist (IL-1RA) is a critical member of the IL-1 family of cytokines, which plays a significant role in modulating inflammatory responses. IL-1RA exists in two main forms: a secreted form (sIL-1Ra) and an intracellular form (icIL-1Ra). The secreted form is produced by various cells including monocytes, macrophages, neutrophils, and other cells, while the intracellular form is found in keratinocytes and other epithelial cells, as well as in monocytes and fibroblasts. IL-1RA is important in host defense against endotoxin-induced injury and is produced in numerous experimental animal models of disease, as well as in human autoimmune and chronic inflammatory diseases. It acts as an anti-inflammatory agent by maintaining the balance between pro-inflammatory IL-1α/β and its own anti-inflammatory effects.