IL-21 Polyklonaler Antikörper
IL-21 Polyklonal Antikörper für IHC, Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human, Maus
Anwendung
IHC, Indirect ELISA
Konjugation
Unkonjugiert
Kat-Nr. : 17625-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
17625-1-PBS bindet in IHC, Indirect ELISA IL-21 und zeigt Reaktivität mit human, Maus
| Getestete Reaktivität | human, Maus |
| Wirt / Isotyp | Kaninchen / IgG |
| Klonalität | Polyklonal |
| Typ | Antikörper |
| Immunogen | IL-21 fusion protein Ag11838 |
| Vollständiger Name | interleukin 21 |
| Berechnetes Molekulargewicht | 162 aa, 19 kDa |
| GenBank-Zugangsnummer | BC066258 |
| Gene symbol | IL-21 |
| Gene ID (NCBI) | 59067 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Antigen-Affinitätsreinigung |
| Lagerungspuffer | PBS only |
| Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
Interleukin 21 (IL-21) is a cytokine produced predominantly by cluster of differentiation 4 (CD4+) T-cells and natural killer T-cells. IL-21 is preliminarily expressed in activated cluster of differentiation 4 (CD4+) T-cells and natural killer (NK) T-cells. IL-21 receptor (IL-21R) is a class I cytokine receptor, which requires dimerization with the indispensable common gamma chain (γc) subunit to bind IL-21. IL-21 plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. IL-21 mediates apoptosis in B-CLL cells through up-regulation of the BIM (BH3 family member) and enhances both direct and antibody-dependent cellular cytotoxicity in these cells.



