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IL-22 Rekombinanter Antikörper

IL-22 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250428B5

Kat-Nr. : 82766-15-PBS

Synonyme

IL22, Cytokine Zcyto18, IL 21, IL 22, IL D110

Filter:
  • Western Blot (WB) analysis of various lysates using IL-22 Recombinant antibody (82766-15-RR)

    WB analysis using 82766-15-RR (same clone as 82766-15-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82766-15-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Recombinant protein using IL-22 Recombinant antibody (82766-15-RR)

    WB analysis of Recombinant protein using 82766-15-RR (same clone as 82766-15-PBS)

    Recombinant protein were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82766-15-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

82766-15-PBS bindet in WB, Indirect ELISA IL-22 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen IL-22 fusion protein HZ-1325
Vollständiger Name interleukin 22
Beobachtetes Molekulargewicht20 kDa
GenBank-ZugangsnummerBC066263
Gene symbol IL-22
Gene ID (NCBI) 50616
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, primarily produced by immune cells such as group 3 innate lymphoid cells (ILC3s), Th17 cells, Th22 cells, and γδ T cells (PMID: 25706098). Its unique feature lies in targeting non-immune epithelial and stromal cells, which exclusively express the heterodimeric IL-22 receptor (IL-22R1 and IL-10R2). IL-22 plays a dual role in immunity and tissue homeostasis: it promotes epithelial cell proliferation, regeneration, and barrier integrity through the upregulation of antimicrobial peptides (e.g., defensins) and mucin production, thereby enhancing defense against extracellular pathogens. However, IL-22 can also drive pathological inflammation in autoimmune and chronic inflammatory diseases (e.g., psoriasis, colitis) when dysregulated. This functional dichotomy highlights its context-dependent nature as both a protective mediator and a pathogenic effector (PMID: 20498020).