IL-22 Rekombinanter Antikörper

IL-22 Rekombinant Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

250428B5

Kat-Nr. : 82766-15-RR

Synonyme

IL22, Cytokine Zcyto18, IL 21, IL 22, IL D110

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  WB analysis using 82766-15-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

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  WB analysis of Recombinant protein using 82766-15-RR

  Recombinant protein were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Transfected with Human IL22 CHO cells, Recombinant protein

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

82766-15-RR bindet in WB, ELISA IL-22 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-22 fusion protein HZ-1325
• Vollständiger Name: interleukin 22
• Beobachtetes Molekulargewicht: 20 kDa
• GenBank-Zugangsnummer: BC066263
• Gene symbol: IL-22
• Gene ID (NCBI): 50616
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, primarily produced by immune cells such as group 3 innate lymphoid cells (ILC3s), Th17 cells, Th22 cells, and γδ T cells (PMID: 25706098). Its unique feature lies in targeting non-immune epithelial and stromal cells, which exclusively express the heterodimeric IL-22 receptor (IL-22R1 and IL-10R2). IL-22 plays a dual role in immunity and tissue homeostasis: it promotes epithelial cell proliferation, regeneration, and barrier integrity through the upregulation of antimicrobial peptides (e.g., defensins) and mucin production, thereby enhancing defense against extracellular pathogens. However, IL-22 can also drive pathological inflammation in autoimmune and chronic inflammatory diseases (e.g., psoriasis, colitis) when dysregulated. This functional dichotomy highlights its context-dependent nature as both a protective mediator and a pathogenic effector (PMID: 20498020).