IL-23 p19 Rekombinanter Antikörper

IL-23 p19 Rekombinant Antikörper für FC (Intra)

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC (Intra)

Konjugation

Unkonjugiert

CloneNo.

242139G12

Kat-Nr. : 98392-1-PBS

Synonyme

IL-23 subunit alpha, Il23a, IL-23A, IL-23-A, IL23P19

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  FC experiment of Transfected HEK-293T using 98392-1-RR (same clone as 98392-1-PBS)

  1x10^6 HEK-293T cells(left) and IL23A -transfected HEK-293T cells(right) were stained with 0.25 ug Anti-Mouse IL23A Rabbit RecAb (98392-1-RR, Clone:242139G12) and APC-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98392-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98392-1-RR (same clone as 98392-1-PBS)

  1x10^6 HEK-293T cells(left) and IL23A -transfected HEK-293T cells(right) were stained with 0.25 ug Anti-Mouse IL23A Rabbit RecAb (98392-1-RR, Clone:242139G12)(red), or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and APC-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98392-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

98392-1-PBS bindet in FC (Intra) IL-23 p19 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-23 p19 fusion protein Eg1634
• Vollständiger Name: interleukin 23, alpha subunit p19
• Berechnetes Molekulargewicht: 22 kDa
• GenBank-Zugangsnummer: NM_031252.2
• Gene symbol: Il23a
• Gene ID (NCBI): 83430
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).