IL-23 p19 Monoklonaler Antikörper

IL-23 p19 Monoklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1D5D3

Kat-Nr. : 66196-1-PBS

Synonyme

IL23A, IL-23 subunit alpha, IL 23p19, IL 23A, IL 23 subunit alpha



Geprüfte Anwendungen

Produktinformation

66196-1-PBS bindet in IHC, Indirect ELISA IL-23 p19 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen IL-23 p19 fusion protein Ag19406
Vollständiger Name interleukin 23, alpha subunit p19
Berechnetes Molekulargewicht 189 aa, 21 kDa
GenBank-ZugangsnummerBC066268
Gene symbol IL23A
Gene ID (NCBI) 51561
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interleukin 23 (IL-23) is a member of the IL12 cytokine family and composed of two subunits, IL12p40 and IL23p19. It is produced by antigen presenting cells and has been shown to promote the production and survival of a distinct lineage of T-cells called TH17 cells. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of Il-12Rβ1 and IL-23R. IL-23 is expressed chiefly by the macrophages and DCs. The IL-23R is found on memory T cells, NKT cells, macrophages, DCs, and naive T cells upon activation by TGF-βand IL-6. The main biological effects of IL-23 identified initially consist of stimulation of antigen presentation by DCs, T cell differentiation to Th17 cells, and production of interferon-γ (IFN-γ). IL-23 acts also as an end-stage effector cytokine through direct action on macrophages.