IL-23R Rekombinanter Antikörper

IL-23R Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

240905B5

Kat-Nr. : 98180-1-PBS

Synonyme

IL23R, interleukin 23 receptor, IL-23 receptor, IL 23R, IL 23 receptor

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  FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

  1x10^6 HEK-293T cells or IL-23R-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98180-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98180-1-RR (same clone as 98180-1-PBS)

  1x10^6 HEK-293T cells (left) or IL-23R-transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human IL-23R Rabbit Recombinant Antibody (98180-1-RR, Clone: 240905B5) (red) or Isotype Control (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98180-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98180-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98180-1-RR against Human IL-23R were performed. The affinity constant is 2.83 nM.

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Geprüfte Anwendungen

Produktinformation

98180-1-PBS bindet in FC IL-23R und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Rekombinantes Protein
• Vollständiger Name: interleukin 23 receptor
• Berechnetes Molekulargewicht: 72 kDa
• GenBank-Zugangsnummer: NM_144701.3
• Gene symbol: IL-23R
• Gene ID (NCBI): 149233
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

Interleukin-23 receptor (IL-23R) is a type I cytokine receptor that plays a critical role in immune responses and inflammation. It forms a receptor complex with IL-12Rβ1 and is activated by the cytokine IL-23, which is primarily produced by dendritic cells and activated macrophages (PMID: 39796684). The genetic and epigenetic interactions in the IL-23R/IL-17 axis are associated with elevated expression of IL-17 and inflammatory bowel disease (IBD) pathogenesis (PMID: 21672939).