IL-4RA/CD124 Rekombinanter Antikörper

IL-4RA/CD124 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242262F10

Kat-Nr. : 98276-1-PBS

Synonyme

242262F10, CD124, IL-4 receptor subunit alpha, Il4r, IL-4R subunit alpha

---

• 

  FC experiment of mouse splenocytes using 98276-1-RR (same clone as 98276-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse IL-4RA/CD124 Rabbit RecAb (98276-1-RR, Clone: 242262F10) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse CD45R. Cells were not fixed. This data was developed using the same antibody clone with 98276-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98276-1-RR (same clone as 98276-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse IL-4RA/CD124 Rabbit RecAb (98276-1-RR, Clone: 242262F10) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98276-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

98276-1-PBS bindet in FC IL-4RA/CD124 und zeigt Reaktivität mit Maus

• Getestete Reaktivität: Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-4RA/CD124 fusion protein Eg2176
• Vollständiger Name: interleukin 4 receptor, alpha
• Berechnetes Molekulargewicht: 88 kDa
• GenBank-Zugangsnummer: NM_001008700.3
• Gene symbol: Il4ra
• Gene ID (NCBI): 16190
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein A purfication
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C.

Hintergrundinformationen

IL-4 receptor alpha chain (IL-4RA), also known as CD124, is a transmembrane glycoprotein expressed on a wide variety of hematopoietic and non-hematopoietic cells. It is a receptor for both IL-4 and IL-13. IL-4RA can complex with the common gamma chain (IL-2R gamma or CD132) and utilizes JAK1 and JAK2 for signal transduction, while complexes of IL-4RA with IL-13RA1 subunit mediate signals via JAK2 and Tyk2. The IL-4 response is involved in promoting Th2 differentiation. The IL-4/IL-13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.