IL-4RA/CD124 Rekombinanter Antikörper

IL-4RA/CD124 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

PE Fluorescent Dye

CloneNo.

241824D8

Kat-Nr. : PE-FcA98203

Synonyme

IL4R, CD124, IL 4 binding protein, IL 4 receptor subunit alpha, IL 4R alpha

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  FC experiment of human PBMCs using PE-FcA98203

  1x10^6 human PBMCs were surface stained with FcZero-rAb™ APC Anti-Human CD19 (4G7), and 5 ul PE Anti-Human IL-4RA/CD124 Rabbit RecAb (PE-FcA98203, Clone: 241824D8) or PE Rabbit IgG Isotype Control RecAb (PE-FcA98136, Clone: 240953C9). Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: humane PBMCs

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Produktinformation

PE-FcA98203 bindet in FC IL-4RA/CD124 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-4RA/CD124 fusion protein Eg1684
• Vollständiger Name: interleukin 4 receptor
• Berechnetes Molekulargewicht: 90 kDa
• GenBank-Zugangsnummer: NM_000418.4
• Gene symbol: IL-4R
• Gene ID (NCBI): 3566
• Konjugation: PE Fluorescent Dye
• Excitation/Emission maxima wavelengths: 496 nm, 565 nm / 578 nm
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide and 0.5% BSA
• Lagerungsbedingungen: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Hintergrundinformationen

IL-4 receptor alpha chain (IL-4RA), also known as CD124, is a transmembrane glycoprotein expressed on a wide variety of hematopoietic and non-hematopoietic cells. It is a receptor for both IL-4 and IL-13. IL-4RA can complex with the common gamma chain (IL-2R gamma or CD132) and utilizes JAK1 and JAK2 for signal transduction, while complexes of IL-4RA with IL-13RA1 subunit mediate signals via JAK2 and Tyk2. The IL-4 response is involved in promoting Th2 differentiation. The IL-4/IL-13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.