IL-5RA/CD125 Rekombinanter Antikörper

IL-5RA/CD125 Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

242234C8

Kat-Nr. : 98338-1-RR

Synonyme

IL5RA, CD125, HSIL5R3, IL 5 receptor subunit alpha, IL 5R alpha

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  FC experiment of human peripheral blood leukocyte using 98338-1-RR

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-5RA/CD125 Rabbit RecAb (98338-1-RR, Clone:242234C8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human Siglec-8 Rabbit Recombinant Antibody (CL647-98177, Clone: 241275A5). CD11b+ cells were pre-gated for analysis. Cells were not fixed.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in FC: human peripheral blood leukocytes

Empfohlene Verdünnung

Anwendung	Verdünnung
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

98338-1-RR bindet in FC IL-5RA/CD125 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-5RA/CD125 fusion protein Eg1665
• Vollständiger Name: interleukin 5 receptor, alpha
• Berechnetes Molekulargewicht: 48 kDa
• GenBank-Zugangsnummer: NM_175726.4
• Gene symbol: IL-5RA/CD125
• Gene ID (NCBI): 3568
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.09% sodium azide
• Lagerungsbedingungen: Store at 2 - 8°C. Stable for one year after shipment.

Hintergrundinformationen

Interleukin-5 receptor subunit alpha (IL-5RA), also known as CD125, is a type I transmembrane protein that belongs to the type I cytokine receptor family. IL-5RA is a critical component of the high-affinity IL-5 receptor complex, IL-5R, which consists of the alpha chain (IL-5RA) that specifically binds to IL-5 and the common beta chain (CD131) shared with receptors for IL-3 and GM-CSF (PMID: 1833065; 7872157). IL-5/IL-5RA signaling axis is crucial for the differentiation, proliferation, recruitment, and activation of eosinophils, and is also involved in pathological eosinophilia (PMID: 34638583).