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IL-6 Monoklonaler Antikörper

IL-6 Monoklonal Antikörper für WB, IF/ICC, ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, ELISA

Konjugation

Unkonjugiert

CloneNo.

1A3B4

Kat-Nr. : 66146-1-PBS

Synonyme

IL6, Interferon beta-2, IL 6, IFN-beta-2, B-cell stimulatory factor 2



Geprüfte Anwendungen

Produktinformation

66146-1-PBS bindet in WB, IF/ICC, ELISA IL-6 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2b
Klonalität Monoklonal
Typ Antikörper
Immunogen IL-6 fusion protein Ag10646
Vollständiger Name interleukin 6 (interferon, beta 2)
Berechnetes Molekulargewicht 212 aa, 24 kDa
Beobachtetes Molekulargewicht24 kDa
GenBank-ZugangsnummerBC015511
Gene symbol IL6
Gene ID (NCBI) 3569
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.