IL-13RA2 Rekombinanter Antikörper

IL-13RA2 Rekombinant Antikörper für WB, Cytometric bead array, Indirect ELISA, Sample test

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Cytometric bead array, Indirect ELISA, Sample test

Konjugation

Unkonjugiert

CloneNo.

250952D10

Kat-Nr. : 86298-2-PBS

Synonyme

IL13RA2, CD213A2, CT19, IL 13 receptor subunit alpha 2, IL 13R

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  WB analysis of A375 using 86298-2-RR (same clone as 86298-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86298-2-RR (IL-13RA2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86298-2-PBS in a different storage buffer formulation.

• 

  Sample test of MP02369-1

  The mean IL-13RA2 concentration was determined to be 75.2 ng/mL in A375 cell extract based on a 1.6 mg/mL extract load.

• 

  Cytometric bead array standard curve of MP02369-1

  Cytometric bead array standard curve of MP02369-1, IL-13RA2 Recombinant Matched Antibody Pair, PBS Only. Capture antibody: 86298-2-PBS. Detection antibody: 86298-1-PBS. Standard: Eg2579. Range: 0.781-100 ng/mL.

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Geprüfte Anwendungen

Produktinformation

86298-2-PBS bindet in WB, Cytometric bead array, Indirect ELISA, Sample test IL-13RA2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: IL-13RA2 fusion protein Eg2579
• Vollständiger Name: interleukin 13 receptor, alpha 2
• Berechnetes Molekulargewicht: 380 aa, 44 kDa
• Beobachtetes Molekulargewicht: 60 kDa
• GenBank-Zugangsnummer: BC020739
• Gene symbol: IL13RA2
• Gene ID (NCBI): 3598
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IL-13RA2, also named as IL-13R and CD213a2, belongs to the type I cytokine receptor family. It binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). IL-13RA2 lacks the cytoplasmic domain for signaling, indicating that it acts as a decoy receptor. IL-13RA2 gene polymorphisms have been associated with systemic sclerosis (PMID: 16981293). Overexpression of IL-13RA2 gene has been reported in several types of cancer, including melanoma, lung cancer, and brain tumor, which makes it a potential immunotherapeutic target (PMID: 19895199; 24970476; 24021875).