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INPP5A Rekombinanter Antikörper

INPP5A Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250584C3

Kat-Nr. : 86001-1-PBS

Synonyme

43 kDa inositol polyphosphate 5-phosphatase, 5PTASE, EC:3.1.3.56, Inositol polyphosphate-5-phosphatase A, Type I inositol 1,4,5-trisphosphate 5-phosphatase

Filter:
  • Western Blot (WB) analysis of various lysates using INPP5A Recombinant antibody (86001-1-RR)

    WB analysis using 86001-1-RR (same clone as 86001-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86001-1-RR (INPP5A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86001-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86001-1-RR

    Affinity and Kinetic Characterization of 86001-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86001-1-RR against Human INPP5A were performed. The affinity constant is below 1 pM.

Geprüfte Anwendungen

Produktinformation

86001-1-PBS bindet in WB, Indirect ELISA INPP5A und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen INPP5A fusion protein Ag16380
Vollständiger Name inositol polyphosphate-5-phosphatase, 40kDa
Berechnetes Molekulargewicht 412 aa, 48 kDa
Beobachtetes Molekulargewicht45 kDa
GenBank-ZugangsnummerBC096280
Gene symbol INPP5A
Gene ID (NCBI) 3632
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

INPP5A (Inositol Polyphosphate-5-Phosphatase A) is a membrane-bound type I inositol 1,4,5-trisphosphate 5-phosphatase that is involved in the mobilization of intracellular calcium ions and the regulation of cellular responses to stimuli. It terminates calcium signaling by hydrolyzing inositol 1,4,5-trisphosphate (InsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). INPP5A plays important roles in various cellular processes, including cell proliferation, apoptosis, vesicular transport, and insulin signaling. Additionally, INPP5A is crucial for the survival of cerebellar Purkinje cells. In certain cancers, such as cutaneous squamous cell carcinoma (cSCC) and esophageal squamous cell carcinoma (ESCC), the expression levels of INPP5A are closely related to disease progression and prognosis.