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INSIG1 Rekombinanter Antikörper

INSIG1 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241353C7

Kat-Nr. : 84352-1-PBS

Synonyme

241353C7, CL 6, INSIG 1, INSIG-1, insulin induced gene 1

Filter:
  • Western Blot (WB) analysis of various lysates using INSIG1 Recombinant antibody (84352-1-RR)

    WB analysis using 84352-1-RR (same clone as 84352-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84352-1-RR (INSIG1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84352-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84352-1-PBS bindet in WB, Indirect ELISA INSIG1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name insulin induced gene 1
Berechnetes Molekulargewicht 30 kDa
Beobachtetes Molekulargewicht35 kDa
GenBank-ZugangsnummerNM_005542
Gene symbol INSIG1
Gene ID (NCBI) 3638
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Insulin-induced genes (INSIGs), which consist of two isoforms (INSIG1 and INSIG2), are representative endoplasmic reticulum (ER)-resident oxysterol-binding proteins (OSBPs). INSIG1 is part of negative regulatory feedback, acting as a brake on SREBP transcriptional function (PMID: 23919961). INSIG1 also has a secondary function mediating sterolaccelerated proteolytic degradation of HMG CoA reductase, thus impacting the mevalonate pathway. Suppression of INSIG1 function promotes hepatic lipid remodelling and restrains NASH (non-alcoholic steatohepatitis) progression (PMID: 33722690).