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IRS4 Polyklonaler Antikörper

IRS4 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 31012-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using IRS4 Polyclonal antibody (31012-1-AP)

    WB analysis using 31012-1-AP (same clone as 31012-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31012-1-AP (IRS4 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31012-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

31012-1-PBS bindet in WB, Indirect ELISA IRS4 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen IRS4 fusion protein Ag34046
Vollständiger Name insulin receptor substrate 4
Berechnetes Molekulargewicht 1257 aa, 135 kDa
Beobachtetes Molekulargewicht133-140 kDa
GenBank-ZugangsnummerBC156977
Gene symbol IRS4
Gene ID (NCBI) 8471
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

IRS4 (Insulin receptor substrate 4), it is expected to be located in the cell membrane, which is expressed in myoblasts, liver and hepatocellular carcinoma. Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. The molecular weight of IRS4 is 133 kDa. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.